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Safety of Testosterone Therapy & Clueless Primary Care Physicians
Testosterone replacement therapy for hypogonadal men has been used for decades. However, there are still scores of primary care doctors spreading irresponsible misinformation regarding the safety of this treatment, particularly to elderly men who can benefit mightily from a balanced hormonal health.
A study was done with 255 men with an Average age of 60.6 ± 8.0 years, with testosterone levels between ≤ 3.5 ng/ml. They received parenteral (injectable) testosterone undecanoate.
After more than five years of monitored testosterone therapy , the study noted that a mere 3 out of 255 patients were diagnosed with prostate cancer. The study stated that “3/255 patients with prostate cancer does not suggest an increased risk of prostate cancer in elderly men on long-term testosterone treatment. Long-term treatment with testosterone undecanoate with monitoring according to the guidelines is acceptably safe.”
Now, according to cancer.org, “About 1 man in 6 will be diagnosed with prostate cancer during his lifetime.” They also stated, “Prostate cancer can be a serious disease, but most men diagnosed with prostate cancer do not die from it. In fact, more than 2.5 million men in the United States who have been diagnosed with prostate cancer at some point are still alive today.”
In over 50 years of studies and research, there has never been a connection between testosterone levels in men and prostate cancer growth. Moreover, a study from Harvard Medical School in 2006 concluded, “there is not now, nor has there ever been a scientific basis for the belief that testosterone causes prostate cancer to grow.”
Just more evidence that testosterone replacement therapy does not cause cancer or prostate cancer. We can’t explain why leagues of completely clueless primary care doctors still spread baseless accusations that TRT is unsafe.
http://www.cancer.org/cancer/prostateca … statistics
Boston Testosterone is a Testosterone Replacement , Wellness and Preventative Medicine Medical Center that treats and prevents the signs and symptoms associated with Andropause and hormone imbalances. With affiliates nationally, Boston Testosterone offers hormone replacement therapy, weight loss protocols, erectile dysfunction (ED), Sermorelin-GHRP2 therapy and neutraceutical injectable therapies for men and women. Their medical facilities offer physician examinations and treatment programs that incorporate the latest in medical science.
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855.617.MEDS (6337)/781-269-5953
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See: Side-Effect Profile of Long-Term Treatment of Elderly Hypogonadal Men with Testosterone Undecanoate – Farid Saad, Ahmad Haider, Gheorghe Doros, Louis Gooren. Bayer Pharma AG, Berlin, Germany; Gulf Medical University School of Medicine, Ajman, United Arab Emirates; Private Practice, Bremerhaven, Germany; Public School of Health, Boston University, Boston, MA; VUMC Amsterdam, Amsterdam, Netherlands.
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PDE5 inhibitors – Another reason to love them
Boston Testosterone Partners /Core New England – Testosterone Replacement Therapy for Men with adjunct therapies in PDE5 inhibitors such as tadalafil (Cialis) and Sildenafil (Viagra). Here is another reason why many of our patients love to include tadalafil troches into their therapy protocols.
Researchers from the University of Bonn treated mice with Viagra and made an amazing discovery: The drug converts undesirable white fat cells and could thus potentially melt the unwelcome “spare tire” around the midriff. In addition, the substance also decreases the risk of other complications caused by obesity. The results are now published in “The Journal of the Federation of American Societies for Experimental Biology ” ( FASEB ).
Sildenafil – better known as Viagra – is used to treat erectile dysfunction. This substance prevents degradation of cyclic guanosine mono-phosphate (cGMP), which then ensures blood supply for an erection. However, another effect of Viagra has been noticed quite some time ago – mice given sildenafil over longer periods of time were resistant to obesity when fed with high-fat diet. However, the cause for this reduced weight gain had been unclear. Researchers from the University of Bonn have been able to shed some light on this sildenafil effect. “We have been researching the effect of cGMP on fat cells for quite some time now,” reports Prof. Dr. Alexander Pfeifer, Director of the Institute for Pharmacology and Toxicology at the University of Bonn. “This is why sildenafil was a potentially interesting candidate for us.”
Viagra converts undesirable white fat cells into beige ones
Together with the PharmaCenter of the University of Bonn, the German Federal Institute for Drugs and Medical Devices (BfArM), and the Max Planck Institute for Heart and Lung Research, the team around Prof. Pfeifer studied the effect of sildenafil on fat cells in mice. The researchers administered the potency drug to the rodents for seven days. “The effects were quite amazing,” says Dr. Ana Kilic, one of Prof. Pfeifer’s colleagues. Sildenafil increased the conversion of white fat cells, which are found in human ‘problem areas’, into beige ones in the animals. “Beige fat cells burn the energy from ingested food and convert it to heat, says Prof. Pfeifer. Because the beige fat cells can “melt the fat” and thus fight obesity, researchers are very hopeful for their potential.
Positive effect on inflammation responses
In addition, the researchers observed something else of interest. If white fat cells are further “stuffed”/accumulating lipids, they are increasing in size and can synthesize and release hormones which in turn cause inflammation thus increasing the persons risk for chronic diseases. Such inflammatory responses may then lead to, e.g., cardio-vascular diseases resulting in heart attacks and strokes, as well as cancer and diabetes. “It seems that sildenafil prevented the fat cells in these mice from getting onto that slippery slope,” reports Prof. Pfeifer. Overall, the development of white cells seems to be healthier.
More than half a billion overweight people worldwide
Globally, over half a billion people are overweight. Present study has resulted in interesting starting points for further research on this mechanism. “Sildenafil is not only able to minimize erectile problems, but it can also reduce the risks of gaining excessive weight,” says Prof. Pfeifer. The researchers may have found a mechanism that allows converting the undesirable white fat cells into the “good” beige (brown-like) fat cells that “melt” away excess pounds. In addition, it might be possible to decrease complications related with obesity. “But this will need to be proven in additional studies,” adds Dr. Kilic.
Caution against premature application
Despite promising data, researchers caution the public against the fallacy of thinking that popping some sildenafil will work to quickly lose the extra pounds accumulated over the holidays. “We are currently in the basic research stage, and all the studies have been exclusively performed on mice,” stresses Prof. Pfeifer. It will be a long way until potentially suitable drugs for decreasing white fat cells in humans will be found.
Source: University of Bonn
Boston Testosterone Partners – At our National Men’s Testosterone Replacement Therapy Clinic in Boston, Massachusetts, many of our patients are treated with Tadalafil (Cialis) sublingual troches 6.25mg daily that work amazing to increase blood flow for ED. However, most everyone finds a great benefit while weight training as blood flow to the muscle is increased as well resulting in a “muscle pump”.
Coupled with our testosterone replacement therapy, the protocols work wonders for men.
For more information contact:
CBlaisdell@corenewengland.com
781-269-5953