We aimed to evaluate the efficacy of tadalafil 5 mg once-daily treatment on
levels in patients with erectile dysfunction (ED) accompanied by the metabolic
syndrome. A total of 40 men with metabolic syndrome were evaluated for
ED in this study. All the patients received 5 mg tadalafil once a day
for 3 months. Erectile function was assessed using the five-item version
of the International Index of Erectile Function (IIEF) questionnaire.
Serum testosterone, follicle-stimulating hormone and luteinising hormone
levels were also evaluated, and blood samples were taken between 08.00
and 10.00 in the fasting state. All participants have three or more criteria
of metabolic syndrome. At the end of 3 months, mean testosterone values
and IIEF scores showed an improvement from baseline values (from 3.6 ±
0.5 to 5.2 ± 0.3, from 11.3 ± 1.9 to 19 ± 0.8 respectively).
After the treatment, serum LH levels were decreased (from 5.6 ±
0.6 to 4.6 ± 0.5). There was significantly difference in terms
of baseline testosterone and luteinising hormone values and IIEF scores
(p < .05). Based on our findings, we recommend tadalafil 5 mg once
daily in those men with erectile dysfunction especially low testosterone
levels accompanied by metabolic syndrome.
Article Source: https://www.ncbi.nlm.nih.gov/pubmed/28295481
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